NIAID funds a variety of programs that provide resources to influenza researchers in their achievement of the Universal Influenza Vaccine Strategic Plan objectives. Those resources are readily available to all researchers and are accessible below. The content cited is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Supports the design, development, implementation, and conduct of Phase 0 through Phase 2 clinical trials

A searchable database of influenza clinical studies and related biological samples

  • Vaccine Treatment and Evaluation Units (VTEU) Clinical Trial Samples

Provides samples collected in VTEU clinical trials. Contact Dr. Brooke Bozick at brooke.bozick@nih.gov

Provides expertise in the areas of biostatistics, microarray analysis, sequence analysis, structural biology, and phylogenetics

Provides computational platforms and analysis tools to support genomics and related research

Provides software tools developed by CEIRR investigators for researching influenza and related pathogens

Distributes data, software, and reagents related to gene characterization and genome annotation

Provides clinical trials management support services to NIAID-funded research

Provides bioinformatics software tools and methodologies to support influenza genomic analysis

Multidisciplinary team that supports the integration of large-scale biological and clinical data

Incorporates all aspects of the depreciated Influenza Research Database to provide comprehensive viral data, analysis tools, and workspaces

Provide a database of 3-D protein structures and protein-ligand complexes, deliver 3-D structure determination, and provide molecular screening of proteins in complex with inhibitors, cofactors and substrate analogs

The NIAID Data Ecosystem Discovery Portal enables users to find datasets from a wide range of repositories and offers a convenient one-stop-shop for discovery of data on infectious and immune-mediated diseases (IIDs)

Repository of immunological data and associated metadata

Database of antibodies and epitopes studied in humans, primates, and other animals

Collection of data browsers for mouse genome, gene expression, and immune system investigation

Data management and analysis engine to access HIPC study data

Manages and coordinates data processing, data analysis, and communication needs for the CEIRR Network

Provides statistical analysis, data management and analytics, preclinical and clinical study coordination services, and communication support for the CIVICs cores

Provides adjuvant metadata produced by NIAID-funded studies and fosters collaboration between the Adjuvant Development Program and the scientific community

Assigns the genotype/subtype of a virus, based on the genotype/subtype assignments maintained by the International Committee on Taxonomy of Viruses (ICTV)

Looks for positions that significantly differ between user-defined groups of sequences

Implements logistic regression for classification of sequences based on a reference set

Generates visualizations of mutations between pairs of HA sequences

Uses BLAST to identify segments from a curated database

An R package to reconstruct birth year-specific probabilities of imprinting to influenza A, H1N1, H2N2, H3N2

An open-source project to harness the scientific and public health potential of pathogen genome data

Nextrain tracking of H5Nx virus evolution via Phylogeny, Geography, and Nucleotide diversity of genome

Identifies taxa that best represent diversity on a phylogenetic tree

Quantifies phylogenetic diversity and associated descriptive statistics for all clades in a phylogeny

Models mutational escape from polyclonal antibodies using deep mutational scanning data

A command-line application for manipulating phylogenies that includes algorithms for subsampling, filtering, and classifying phylogenetic trees

Collection of services to support product development of in vitro diagnostics

Provides a broad range of in vitro assessments to evaluate promising candidate countermeasures for antimicrobial activity

Services to support the development and improvement of animal infectious disease models

Services to support the development of products intended for use in the cure, mitigation, diagnosis, or treatment of diseases caused by a pathogen

These research programs focus on discovery, development, and characterization of new vaccine adjuvants

Collection of services to support vaccine development

Provides cultures and reagents for microbiology and infectious diseases research

Provides plasmids, viral isolates, proteins, antibodies, reverse-engineered viruses, and cells for influenza research

Provides antibodies, ferret blood material, ferret cells, proteins and ferret tissue for influenza research

Provides major histocompatibility complex tetramers and other reagents to detect T cell responses

Provides Good Manufacturing Practice (GMP)-quality candidate vaccine viruses for zoonotic influenza which have been used to create H5, H9, and H7 vaccine lots

This integrated research facility fine-tunes Aerosolization procedures to achieve accurate and precise dosimetry

This integrated research facility develops animal models of disease using high-consequence viral pathogens that accurately recapitulate human disease

This integrated research facility uses varied EM capabilities for the analysis of biological samples at an ultrastructural level

This integrated research facility uses In vivo imaging to provide meaningful information for the characterization of infectious diseases

This integrated research facility interrogates immune responses against pathogens requiring maximum containment by use of a variety of capabilities

These research facilities provide BSL4/3/2 and BSL3/2 biocontainment for research on biodefense and emerging infectious disease agents

This integrated research facility conducts morphologic assessments and molecular assays using in-life and postmortem samples attained during research studies

The Dale and Betty Bumpers Vaccine Research Center (VRC) at the National Institutes of Health (NIH) was established to facilitate research in vaccine development

This integrated research facility focuses on gaining a deeper understanding of viral pathogenesis and advancing clinical approaches to assist in managing diseases