Resources
NIAID funds a variety of programs that provide resources to influenza researchers in their achievement of the Universal Influenza Vaccine Strategic Plan objectives. Those resources are readily available to all researchers and are accessible below. The con
Clinical Resources
Supports the design, development, implementation, and conduct of Phase 0 through Phase 2 clinical trials
A searchable database of influenza clinical studies and related biological samples
Provides samples collected in VTEU clinical trials. Contact Dr. Brooke Bozick at brooke.bozick@nih.gov
Computational Resources
Provides expertise in the areas of biostatistics, microarray analysis, sequence analysis, structural biology, and phylogenetics
Provides computational platforms and analysis tools to support genomics and related research
Provides software tools developed by CEIRR investigators for researching influenza and related pathogens
Distributes data, software, and reagents related to gene characterization and genome annotation
Provides clinical trials management support services to NIAID-funded research
Provides bioinformatics software tools and methodologies to support influenza genomic analysis
Multidisciplinary team that supports the integration of large-scale biological and clinical data
Databases, Knowledgebases & Analytics
Incorporates all aspects of the depreciated Influenza Research Database to provide comprehensive viral data, analysis tools, and workspaces
Provide a database of 3-D protein structures and protein-ligand complexes, deliver 3-D structure determination, and provide molecular screening of proteins in complex with inhibitors, cofactors and substrate analogs
The NIAID Data Ecosystem Discovery Portal enables users to find datasets from a wide range of repositories and offers a convenient one-stop-shop for discovery of data on infectious and immune-mediated diseases (IIDs)
Repository of immunological data and associated metadata
Database of antibodies and epitopes studied in humans, primates, and other animals
Collection of data browsers for mouse genome, gene expression, and immune system investigation
Data management and analysis engine to access HIPC study data
Manages and coordinates data processing, data analysis, and communication needs for the CEIRR Network
Provides statistical analysis, data management and analytics, preclinical and clinical study coordination services, and communication support for the CIVICs cores
Provides adjuvant metadata produced by NIAID-funded studies and fosters collaboration between the Adjuvant Development Program and the scientific community
GitHub Resources
Assigns the genotype/subtype of a virus, based on the genotype/subtype assignments maintained by the International Committee on Taxonomy of Viruses (ICTV)
Looks for positions that significantly differ between user-defined groups of sequences
Implements logistic regression for classification of sequences based on a reference set
Generates visualizations of mutations between pairs of HA sequences
Uses BLAST to identify segments from a curated database
An R package to reconstruct birth year-specific probabilities of imprinting to influenza A, H1N1, H2N2, H3N2
An open-source project to harness the scientific and public health potential of pathogen genome data
Nextrain tracking of H5Nx virus evolution via Phylogeny, Geography, and Nucleotide diversity of genome
Identifies taxa that best represent diversity on a phylogenetic tree
Quantifies phylogenetic diversity and associated descriptive statistics for all clades in a phylogeny
Models mutational escape from polyclonal antibodies using deep mutational scanning data
A command-line application for manipulating phylogenies that includes algorithms for subsampling, filtering, and classifying phylogenetic trees
Pre-Clinical Services
Collection of services to support product development of in vitro diagnostics
Provides a broad range of in vitro assessments to evaluate promising candidate countermeasures for antimicrobial activity
Services to support the development and improvement of animal infectious disease models
Services to support the development of products intended for use in the cure, mitigation, diagnosis, or treatment of diseases caused by a pathogen
These research programs focus on discovery, development, and characterization of new vaccine adjuvants
Collection of services to support vaccine development
Reagents
Provides cultures and reagents for microbiology and infectious diseases research
Provides plasmids, viral isolates, proteins, antibodies, reverse-engineered viruses, and cells for influenza research
Provides antibodies, ferret blood material, ferret cells, proteins and ferret tissue for influenza research
Provides major histocompatibility complex tetramers and other reagents to detect T cell responses
Provides Good Manufacturing Practice (GMP)-quality candidate vaccine viruses for zoonotic influenza which have been used to create H5, H9, and H7 vaccine lots
Research Facilities
This integrated research facility fine-tunes Aerosolization procedures to achieve accurate and precise dosimetry
This integrated research facility develops animal models of disease using high-consequence viral pathogens that accurately recapitulate human disease
This integrated research facility uses varied EM capabilities for the analysis of biological samples at an ultrastructural level
This integrated research facility uses In vivo imaging to provide meaningful information for the characterization of infectious diseases
This integrated research facility interrogates immune responses against pathogens requiring maximum containment by use of a variety of capabilities
These research facilities provide BSL4/3/2 and BSL3/2 biocontainment for research on biodefense and emerging infectious disease agents
This integrated research facility conducts morphologic assessments and molecular assays using in-life and postmortem samples attained during research studies
The Dale and Betty Bumpers Vaccine Research Center (VRC) at the National Institutes of Health (NIH) was established to facilitate research in vaccine development
This integrated research facility focuses on gaining a deeper understanding of viral pathogenesis and advancing clinical approaches to assist in managing diseases